Yes

For every pixel of knowledge you are aware of, there must be something that has that intrinsic colorness quality of each of those pixels. If the intrinsic nature of any one of the pixels changes from redness to greenness, or anything else, that pixel of knowledge would be qualitatively different. We must be able to objectively observe and describe any and all physical changes to any and all pixels of subjective knowledge. If any of the pixels were compressed or optimized, you couldn't be aware of each of them. The same as you must uncompress an optimized image, before you can render it on each pixel of a TV screen.